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KMID : 0378019670100070101
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New Medical Journal
1967 Volume.10 No. 7 p.101 ~ p.110
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The Effect of Sex Hormones on Glutamic acid Metabolism in a Bone
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Abstract
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The effect of sex hormones, estrogen, androgen & progesterone in the metabolism of protein in the fractured and intact femur homogenate of mice was studied.
The femur homogenate was incubated with glutamic acid-U-1} C. CO, production and it´s specific activity (cpm/mg CO,) weight of protein and it´s specific activity (cpm/mg Protein), and nonprotein filtrate and it´s radioactivity were determined.
Sex hormones which were given intraperitoneally resulted in a significant increase of CO, production, and decrease of specific activity.
They also resulted in an increase of weight of protein and it´s specific activity, and decrease of radioactivity of non-protein filtrate as compared with normal control. Of three sex hormones, androgen had the most potent effect.
These effects of sex hormones were augmented by fracture itself.
It was also demonstrated that sex hormones exerted the same effects on femur homogenate which was incubated with sex hormones in vitro.
It is apparent from this study that sex hormones and fracture promote protein synthesis and oxidative metabolism in a bone, and the mode of action of the hormones are direct.
It is also apparent that incorporation of an amino acid into protein is increased by sex hormones and fracture, but utilization of amino acid in oxidative metabolism is decreased by them.
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